pd.pivot_table

>>> table = pd.pivot_table(df, values='D', index=['A', 'B'],
...                     columns=['C'], aggfunc=np.sum, fill_value=0)
>>> table
C        large  small
A   B
bar one      4      5
    two      7      6
foo one      4      1
    two      0      6

>>> table = pd.pivot_table(df, values=['D', 'E'], index=['A', 'C'],
...                     aggfunc={'D': np.mean,
...                              'E': [min, max, np.mean]})
>>> table
                D    E
            mean  max      mean  min
A   C
bar large  5.500000  9.0  7.500000  6.0
    small  5.500000  9.0  8.500000  8.0
foo large  2.000000  5.0  4.500000  4.0
    small  2.333333  6.0  4.333333  2.0

>>> df = pd.DataFrame({"A": ["foo", "foo", "foo", "foo", "foo",
...                          "bar", "bar", "bar", "bar"],
...                    "B": ["one", "one", "one", "two", "two",
...                          "one", "one", "two", "two"],
...                    "C": ["small", "large", "large", "small",
...                          "small", "large", "small", "small",
...                          "large"],
...                    "D": [1, 2, 2, 3, 3, 4, 5, 6, 7],
...                    "E": [2, 4, 5, 5, 6, 6, 8, 9, 9]})
>>> df
     A    B      C  D  E
0  foo  one  small  1  2
1  foo  one  large  2  4
2  foo  one  large  2  5
3  foo  two  small  3  5
4  foo  two  small  3  6
5  bar  one  large  4  6
6  bar  one  small  5  8
7  bar  two  small  6  9
8  bar  two  large  7  9